Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

Nagalingam R. Sundaresan, Madhu Gupta, Gene Kim, +3

Journal of Clinical Investigation

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Nagalingam R. Sundaresan, Prabhakaran Vasudevan, Lei Zhong, +12

Nature Medicine

Cardiac MuscleCardiomyopathyMolecular PhysiologySignaling PathwayCardiac Hypertrophy +7

The design and implementation of tripwire

Gene Kim, Eugene H. Spafford

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

Vinodkumar B. Pillai, Sadhana Samant, Nagalingam R. Sundaresan, +8

Nature Communications

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

Vinodkumar B. Pillai, Nagalingam R. Sundaresan, Gene Kim, +7

Journal of Biological Chemistry

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

Stephen L. Archer, Glenn Marsboom, Gene Kim, +9

Circulation

The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10- Year Update

Diyar Saeed, David S. Feldman, Aly El Banayosy, +82

The Journal of Heart and Lung Transplantation

Transplantation SurgeryAssisted CirculationHeart FailureCardiothoracic SurgeryCardiovascular Disease +9

Hemodynamic Ramp Tests in Patients With Left Ventricular Assist Devices

Nir Uriel, G. Sayer, Karima Addetia, +13

JACC Heart Failure

Heart FailureAssistive TechnologyCardiovascular DiseaseHemodynamic Ramp TestsDevice Therapy +5

TBX5 drives Scn5a expression to regulate cardiac conduction system function

David E. Arnolds, Fang Liu, John Fahrenbach, +7

Journal of Clinical Investigation

Cardiac MuscleGeneticsCcs FunctionGene Regulatory NetworkCardiovascular Function +16

Association of Clinical Outcomes With Left Ventricular Assist Device Use by Bridge to Transplant or Destination Therapy Intent

Daniel J. Goldstein, Yoshifumi Naka, Douglas Horstmanshof, +16

JAMA Cardiology