Frederick W. Alt

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Anne Brunet, Lora B. Sweeney, James Fitzhugh Sturgill et al. · Science · 2004 · 3.2K citations

Life Sciences, Biochemistry, Molecular Biology +15

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

Matthew D. Hirschey, Tadahiro Shimazu, Eric S. Goetzman et al. · Nature · 2010 · 1.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Raúl Mostoslavsky, Katrin F. Chua, David B. Lombard et al. · Cell · 2006 · 1.6K citations · Full text

Medicine, Genetics, Molecular Biology +16

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

In Hye Lee, Liu Cao, Raúl Mostoslavsky et al. · Proceedings of the National Academy of Sciences · 2008 · 1.4K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

An early haematopoietic defect in mice lacking the transcription factor GATA-2

Fong‐Ying Tsai, Gordon Keller, Frank C. Kuo et al. · Nature · 1994 · 1.4K citations

Life Sciences, Hematology, Molecular Biology +10