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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Selene Glück, Baptiste Guey, Muhammet F. Gülen, Katharina Wolter, Tae-Won Kang, Niklas A. Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser

Nature Cell Biology · 2017 · 1.1K citations · 37 references

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37

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Lijun Sun, Jiaxi Wu, Fenghe Du et al. · Science · 2012 · 4.8K citations

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean‐Philippe Coppé · 2008 · 4.1K citations · Full text

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker, Bennett G. Childs, Matej Durik et al. · Nature · 2016 · 2.8K citations · Full text

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Functional Role of Type I and Type II Interferons in Antiviral Defense

Ulrike Müller, Ulrich Steinhoff, Luiz F. L. Reis et al. · Science · 1994 · 2.5K citations · Full text

, , +15

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Wen Xue, Lars Zender, Cornelius Miething et al. · Nature · 2007 · 2.4K citations

, , +16