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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

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Medicine, Cancer Biology, Oncology +16

Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

David M. Berman, Sunil Karhadkar, Andrew R. Hallahan et al. · Science · 2002 · 794 citations

Medicine, Oncology, Pharmacology +17

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice

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Medicine, Molecular Biology, Oncology +14