O-GlcNAcylation of amyloid-β precursor protein at threonine 576 residue regulates trafficking and processing

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Takeshi Iwatsubo, Asano Odaka, Nobuhiro Suzuki et al. · Neuron · 1994 · 1.8K citations

Life Sciences, Neuroscience, Pathology +16

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

Mikio Shoji, Todd E. Golde, Jorge Ghiso et al. · Science · 1992 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +14

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

Andreas Weidemann, Gerhard König, Dirk Bunke et al. · Cell · 1989 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +12

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Edward H. Koo, Sharon L. Squazzo · Journal of Biological Chemistry · 1994 · 991 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17