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Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation

DOIFull Paper Access

108

Citations

33

References

2017

Year

Fayhan Alroqi, Louis‐Marie Charbonnier, Janet Chou, Craig D. Platt, Abdulrahman Algassim, Sevgi Keleş, Bandar K. Al Saud, Fowzan S. Alkuraya, Michael B. Jordan, Raif S. Geha,
Journal of Allergy and Clinical Immunology

Abstract

cT<sub>FH</sub> cell dysregulation in patients with LRBA deficiency reflects impaired control of T<sub>FH</sub> cell differentiation because of profoundly decreased CTLA4 expression on regulatory T cells and probably contributes to autoimmunity in patients with this disease. Serial monitoring of cT<sub>FH</sub> cell frequencies is highly useful in gauging the clinical response of LRBA-deficient patients to CTLA4-Ig therapy.

References

YearCitations

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