Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

Rimpei Morita, Nathalie Schmitt, Salah-Eddine Bentebibel, +12

Immunity

Autoimmune DiseaseT Follicular CellsLymphocyte DevelopmentContain Specific SubsetsImmunology +9

Induction of ICOS ⁺ CXCR3 ⁺ CXCR5 ⁺ T _H Cells Correlates with Antibody Responses to Influenza Vaccination

Salah-Eddine Bentebibel, Santiago M. C. Lopez, Gerlinde Obermoser, +14

Science Translational Medicine

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

Nathalie Schmitt, Yang Liu, Salah-Eddine Bentebibel, +5

Nature Immunology

Cytokine Tgf-β Co-optsTranscriptional RegulationHuman Tfh CellsSignal TransductionSignaling Pathway +6

Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity

Yared Hailemichael, Daniel H. Johnson, Noha Abdel‐Wahab, +34

Cancer Cell

Immune EvasionTumor ImmunologyCancer ImmunosurveillanceImmunologyTumor Immunity +3

Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02)

Adi Diab, Nizar M. Tannir, Salah-Eddine Bentebibel, +20

Cancer Discovery

A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rβγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors

Salah-Eddine Bentebibel, Michael E. Hurwitz, Chantale Bernatchez, +14

Cancer Discovery

ICOS+PD-1+CXCR3+ T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

Salah-Eddine Bentebibel, Surender Khurana, Nathalie Schmitt, +8

Scientific Reports

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy

Meenu Sharma, Hiep Khong, Faisal Fa’ak, +28

Nature Communications

Human tonsil <i>B</i> - <i>cell lymphoma 6</i> ( <i>BCL6</i> )-expressing CD4 ⁺ T-cell subset specialized for B-cell help outside germinal centers

Salah-Eddine Bentebibel, Nathalie Schmitt, Jacques Banchereau, +1

Proceedings of the National Academy of Sciences

Distinct tumor-infiltrating lymphocyte landscapes are associated with clinical outcomes in localized non-small-cell lung cancer

Lorenzo Federico, Daniel J. McGrail, Salah-Eddine Bentebibel, +33

Annals of Oncology

Cancer ImmunosurveillanceMedicineImmunologyTumor ImmunityPathology +6