Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

Vancheswaran Gopalakrishnan, Christine N. Spencer, Luigi Nezi, +67

Science

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

Pei-Ling Chen, Whijae Roh, Alexandre Reuben, +41

Cancer Discovery

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

Whijae Roh, Pei-Ling Chen, Alexandre Reuben, +37

Science Translational Medicine

T-regulatory CellImmunologyPathologyImmune Checkpoint BlockadeImmunotherapy +16

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

Christine N. Spencer, Jennifer L. McQuade, Vancheswaran Gopalakrishnan, +86

Science

NutritionDysbiosisGut BacteriaImmunologyDietary Fibre +26

Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

Rodabe N. Amaria, Sangeetha M. Reddy, Hussein A. Tawbi, +42

Nature Medicine

MedicineMelanomaImmunologyTumor ImmunityImmune Checkpoint Inhibitor +3

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Miles C. Andrews, Connie P.M. Duong, Vancheswaran Gopalakrishnan, +68

Nature Medicine

DysbiosisHealth SciencesMucosal ImmunologyPd-1 BlockadeMedicine +11

Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma

Catherine S. Grasso, Jennifer Tsoi, Mykola Onyshchenko, +33

Cancer Cell

Tumor ImmunologyCancer ImmunosurveillanceMelanomaImmunologyTumor Immunity +5

Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity

Yared Hailemichael, Daniel H. Johnson, Noha Abdel‐Wahab, +34

Cancer Cell

Immune EvasionTumor ImmunologyCancer ImmunosurveillanceImmunologyTumor Immunity +3

Neoadjuvant relatlimab and nivolumab in resectable melanoma

Rodabe N. Amaria, Michael A. Postow, Elizabeth M. Burton, +37

Nature

Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells

Chad Tang, James W. Welsh, Patricia M. de Groot, +17

Clinical Cancer Research