Blood · 2017 · 155 citations · 58 references
Life SciencesImmunologyMicrobiologyInflammationInnate ImmunitySignal TransductionGut MicrobiomeGut MicrobiotaHepatic PathophysiologyInflammatory SignalingMicrobiome DysbiosisToll-like ReceptorsGut Microbiota DysbiosisToll-like Receptor SignalingToll-like Receptor Signaling PathwaysToll-like Receptor-mediated Innate Immune ResponseVon Willebrand Factor Regulation
mice in vivo. These experiments delineate an unexpected pathway in which microbiota-triggered TLR2 signaling alters the synthesis of proadhesive VWF by the liver endothelium and favors platelet integrin-dependent thrombus growth.
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