Concepedia

Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells

Geoffrey L. Rogers, Jamie L. Shirley, Irene Zolotukhin, Sandeep Kumar, Alexandra Sherman, George Q. Perrin, Brad E. Hoffman, Arun Srivastava, Etiena Basner‐Tschakarjan, Mark A. Wallet,

Blood · 2017 · 123 citations · 48 references

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Concepts

Abstract

Key Points Crosspriming of AAV capsid-specific CD8+ T cells requires cooperation between distinct subsets of DCs. Innate immune sensing of the viral DNA genome induces cross-presentation of viral capsid in trans.

References

48

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Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

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In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

Steffen Jung, Derya Unutmaz, Phillip Wong et al. · Immunity · 2002 · 1.7K citations · Full text

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Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses

Zhong Li, Baozheng Li, Cathryn Mah et al. · Proceedings of the National Academy of Sciences · 2008 · 549 citations · Full text

, , +17