Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

Sergei Zolotukhin, Barry J. Byrne, Emily Grace Mason, +6

Gene Therapy

Novel MethodsInfectious TiterViral ReplicationSynthetic VirologyBiotechnology +4

Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

Sergei Zolotukhin, Mark Potter, Irene Zolotukhin, +10

Methods

Viral ReplicationPathogenesisMolecular BiologyVirologyGene Vector +4

Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses

Zhong Li, Baozheng Li, Cathryn Mah, +11

Proceedings of the National Academy of Sciences

Recombinant Adeno-Associated Virus Serotype 9 Leads to Preferential Cardiac Transduction In Vivo

Christina A. Pacak, Cathryn Mah, Bijoy Thattaliyath, +6

Circulation Research

Cardiac MuscleAav9 Gene TransferVector GenomesImmunologyCardiac Progenitor Cells +14

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver

Ashley T. Martino, Masataka Suzuki, David M. Markusic, +7

Blood

Improved Method of Recombinant AAV2 Delivery for Systemic Targeted Gene Therapy

Cathryn Mah, Thomas J. Fraites, Irene Zolotukhin, +5

Molecular Therapy

EngineeringIn Vivo Gene TherapyRecombinant Aav2 DeliveryImmunologyGene Delivery +15

Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein

D M McCarty, Daniel J. Pereira, Irene Zolotukhin, +3

Journal of Virology

Rep ProteinViral ReplicationGeneticsMolecular BiologyRep Binding Site +14

High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap

James E. Conway, CMJ ap Rhys, Irene Zolotukhin, +4

Gene Therapy

Synthetic VirologyPathogenesisImmunologyVirologyAav-2 Rep +3

Correction of the Enzymatic and Functional Deficits in a Model of Pompe Disease Using Adeno-associated Virus Vectors

Thomas J. Fraites, Mary R. Schleissing, R. Andrew Shanely, +9

Molecular Therapy

High-efficiency Transduction and Correction of Murine Hemophilia B Using AAV2 Vectors Devoid of Multiple Surface-exposed Tyrosines

David M. Markusic, Roland W. Herzog, George Aslanidi, +10

Molecular Therapy