Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 16.7K citations · Full text

Crispr Rnas, Adaptive Bacterial Immunity, Crispr-associated Protein Cas9 +15

DNA targeting specificity of RNA-guided Cas9 nucleases

Patrick D. Hsu, David A. Scott, Joshua A. Weinstein et al. · Nature Biotechnology · 2013 · 4.8K citations · Full text

Molecular Biology, Gene Editing, Genome Editing +3

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

John G. Doench, Ella Hartenian, Daniel B. Graham et al. · Nature Biotechnology · 2014 · 1.7K citations · Full text

Systems Biology, Engineering, Active Sgrnas +9

Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs

James A. Gagnon, Eivind Valen, Summer B. Thyme et al. · PLoS ONE · 2014 · 977 citations · Full text

Efficient Marker-Free Recovery of Custom Genetic Modifications with CRISPR/Cas9 in <i>Caenorhabditis elegans</i>

Joshua A. Arribere, Ryan T. Bell, Becky Xu Hua Fu et al. · Genetics · 2014 · 924 citations · Full text