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SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin

Yuan-Hung Lo, Taeko K. Noah, Min-Shan Chen, Winnie Y. Zou, Ester Borràs, Eduardo Vilar, Noah F. Shroyer

Gastroenterology · 2017 · 42 citations · 41 references

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41

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature · 2009 · 7.2K citations

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Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature · 2007 · 5.7K citations

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Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

Toshiro Sato, Daniel E. Stange, Marc Ferrante et al. · Gastroenterology · 2011 · 3.8K citations · Full text

, , +14

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Toshiro Sato, Johan H. van Es, Hugo J.G. Snippert et al. · Nature · 2010 · 2.5K citations

, , +15

Crypt stem cells as the cells-of-origin of intestinal cancer

Nick Barker, Rachel A. Ridgway, Johan H. van Es et al. · Nature · 2008 · 2.2K citations

, , +14