Scientific Reports · 2017 · 45 citations · 45 references
Life SciencesNeurobiologyNeuroscienceMemoryMolecular NeuroscienceSynaptic PlasticityGlutamatergic SignalingHippocampal SystemsLong-term DepressionLong-term PotentiationNeurodegenerative DiseasesO-linked GlycosylationAmpa Receptor FunctionHippocampal Long-term DepressionHippocampal Long-term PotentiationHippocampal PlasticityLong-term Synaptic PlasticityNeuronal DysfunctionRodent Synaptic PlasticitySynaptic Plasticity Disruption
Abstract O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga +/− mice which have an increased level of O-GlcNAcylation, and found that Oga +/− mice exhibited impaired spatial learning and memory. Consistent with this result, Oga +/− mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory.
45
AMPARs and Synaptic Plasticity: The Last 25 Years
Richard L. Huganir, Roger A. Nicoll · Neuron · 2013 · 971 citations · Full text
Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit
Katherine W. Roche, Richard O’Brien, Andrew L. Mammen et al. · Neuron · 1996 · 810 citations · Full text