Xiaoyang Shan

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

Scott A. Yuzwa, Matthew S. Macauley, Julia Heinonen et al. · Nature Chemical Biology · 2008 · 691 citations · Full text

Signal Transduction, Biochemistry, G Protein-coupled Receptor +9

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

Scott A. Yuzwa, Xiaoyang Shan, Matthew S. Macauley et al. · Nature Chemical Biology · 2012 · 606 citations

Neurodegenerative Diseases, Molecular Neuroscience, Alzheimer's Disease +10

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

Scott A. Yuzwa, Xiaoyang Shan, Bryan A. Jones et al. · Molecular Neurodegeneration · 2014 · 149 citations · Full text

Enhanced De Novo Neurogenesis and Dopaminergic Neurogenesis in the Substantia Nigra of 1‐Methyl‐4‐phyenyl‐1,2,3,6‐Tetrahydropyridine‐Induced Parkinson's Disease‐Like Mice

Xiaoyang Shan, Liying Chi, Michael Bishop et al. · Stem Cells · 2006 · 132 citations · Full text

Novo Neurogenesis, Synaptic Signaling, Social Sciences +20

Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage

Xiaoyang Shan, Liying Chi, Yan Ke et al. · Neurobiology of Disease · 2007 · 105 citations · Full text

Cortical Neurons, Redox Regulator, Neurophysiology +9