Matthew S. Macauley

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

Scott A. Yuzwa, Matthew S. Macauley, Julia Heinonen et al. · Nature Chemical Biology · 2008 · 691 citations · Full text

Signal Transduction, Biochemistry, G Protein-coupled Receptor +9

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

Scott A. Yuzwa, Xiaoyang Shan, Matthew S. Macauley et al. · Nature Chemical Biology · 2012 · 606 citations

Neurodegenerative Diseases, Molecular Neuroscience, Alzheimer's Disease +10

O-GlcNAcase Uses Substrate-assisted Catalysis

Matthew S. Macauley, Garrett E. Whitworth, Aleksandra W. Debowski et al. · Journal of Biological Chemistry · 2005 · 366 citations · Full text

Substrate-assisted Catalysis, Bioorganic Chemistry, Cellular Enzymology +15

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

Laura E. McCoy, Marit J. van Gils, Gabriel Ozorowski et al. · Cell Reports · 2016 · 256 citations · Full text

Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2

Linh Nguyen, Kelli A. McCord, Duong T. Bui et al. · Nature Chemical Biology · 2021 · 252 citations · Full text