Concepedia

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

Scott A. Yuzwa, Xiaoyang Shan, Matthew S. Macauley, Thomas Clark, Yuliya Skorobogatko, Keith Vosseller, David J. Vocadlo

Nature Chemical Biology · 2012 · 615 citations · 46 references

DOI

Concepts

References

46

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

Mike Hutton, Corinne Lendon, Patrizia Rizzu et al. · Nature · 1998 · 3.5K citations

, , +14

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

Karen S. SantaCruz, Jada Lewis, Jennifer Paulson et al. · Science · 2005 · 2K citations · Full text

, , +12

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

Eric van Steen, Benjamin M. Terry, Enrique J. Rivera et al. · Journal of Alzheimer s Disease · 2005 · 1.7K citations

, , +17

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Jada Lewis, Eileen McGowan, Julia M. Rockwood et al. · Nature Genetics · 2000 · 1.4K citations

, , +16

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

Michel Goedert, Ross Jakes, M. G. Spillantini et al. · Nature · 1996 · 1K citations

, , +15