David J. Vocadlo

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

Scott A. Yuzwa, Matthew S. Macauley, Julia Heinonen et al. · Nature Chemical Biology · 2008 · 691 citations · Full text

Signal Transduction, Biochemistry, G Protein-coupled Receptor +9

Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate

David J. Vocadlo, G.J. Davies, Roger A. Laine et al. · Nature · 2001 · 628 citations · Full text

Biochemistry, Natural Sciences, Biocatalysis +7

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

Scott A. Yuzwa, Xiaoyang Shan, Matthew S. Macauley et al. · Nature Chemical Biology · 2012 · 606 citations

Neurodegenerative Diseases, Molecular Neuroscience, Alzheimer's Disease +10

A chemical approach for identifying <i>O</i> -GlcNAc-modified proteins in cells

David J. Vocadlo, Howard C. Hang, Eun-Ju Kim et al. · Proceedings of the National Academy of Sciences · 2003 · 533 citations · Full text

O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway

Christina M. Ferrer, Thomas P. Lynch, Valerie L. Sodi et al. · Molecular Cell · 2014 · 420 citations · Full text

Cancer Metabolism, Tumor Biology, Oncology +12