Novel scaffold evolution through combinatorial 3D-QSAR model studies of two types of JNK3 inhibitors

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

Chia‐Yi Kuan, Derek Yang, Deborah R. Samanta Roy et al. · Neuron · 1999 · 894 citations · Full text

Life Sciences, Developmental Biology, Neuroscience +16

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

Sung Ok Yoon, Dong Ju Park, Jae Cheon Ryu et al. · Neuron · 2012 · 229 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

JNK activation is associated with intracellular β-amyloid accumulation

Mikio Shoji, Noboru Iwakami, Sousuke Takeuchi et al. · Molecular Brain Research · 2000 · 165 citations

Life Sciences, Molecular Biology, Neuroscience +14

Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer’s disease

Carola Otth, Ariadna Mendoza‐Naranjo, Lorena Mujica et al. · Neuroreport · 2003 · 51 citations

Life Sciences, Neurobiology, Neuroscience +17

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

Simeon Bowers, Anh P. Truong, R. Jeffrey Neitz et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 32 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12