Concepedia

Directed Evolution Of Scaffolds

Directed Evolution of Scaffolds is a protein engineering methodology that employs iterative rounds of genetic diversification and selection to optimize the structural and functional properties of protein scaffolds for specific applications.

17

Publications

640

Citations

86

Authors

44

Institutions

Publications per year

2017–2026

8

Parents

Publications

17

Directed evolution of new catalytic activity using the α/β-barrel scaffold

Myriam M. Altamirano, Jonathan M. Blackburn, Cristina Aguayo et al. · Nature · 2000 · 189 citations

, , +16

Nature-inspired design of motif-specific antibody scaffolds

James T. Koerber, N.D. Thomsen, Brett T. Hannigan et al. · Nature Biotechnology · 2013 · 73 citations · Full text

, , +14

Establishing wild-type levels of catalytic activity on natural and artificial (βα) <sub>8</sub> -barrel protein scaffolds

Jörg Claren, Christoph Malisi, Birte Höcker et al. · Proceedings of the National Academy of Sciences · 2009 · 68 citations · Full text

, , +17

Importance of Scaffold Flexibility/Rigidity in the Design and Directed Evolution of Artificial Metallo-β-lactamases

Woon Ju Song, Jaeseung Yu, F. Akif Tezcan · Journal of the American Chemical Society · 2017 · 47 citations

, , +17

Artificial Protein Scaffold System (AProSS): An efficient method to optimize exogenous metabolic pathways in Saccharomyces cerevisiae

Tianyi Li, Xiuqi Chen, Yizhi Cai et al. · Metabolic Engineering · 2018 · 32 citations · Full text

, , +17

1–5 of 17

Authors

86

  1. RS
    Reinhard Sterner

    University of Regensburg, Germany

    2 publications · 84 citations

    2

    h-index

  2. XC
    Xiuqi Chen

    First Affiliated Hospital of GuangXi Medical University, China

    1 publications · 32 citations

    1

    h-index

  3. JY
    Jin Young Kim

    Korea Research Institute of Bioscience and Biotechnology, South Korea

    1 publications · 16 citations

    1

    h-index

  4. GF
    Gustavo Fuertes

    Parc Científic de la Universitat de València, Spain

    1 publications · 10 citations

    1

    h-index

  5. JD
    Junbiao Dai

    Shenzhen Institutes of Advanced Technology, China

    1 publications · 32 citations

    1

    h-index

1–5 of 86

Institutions

44

  1. University of Regensburg

    Regensburg, Germany

    2 h-index

    4 publications

    168 citations

  2. University of California, San Francisco

    San Francisco, United States

    2 h-index

    6 publications

    346 citations

  3. Seoul National University

    Seoul, South Korea

    2 h-index

    6 publications

    158 citations

  4. McGill University

    Montreal, Canada

    1 h-index

    1 publications

    27 citations

  5. Institut de Biochimie et Biophysique Moléculaire et Cellulaire

    Orsay, France

    1 h-index

    9 publications

    198 citations

  6. Tata Institute of Fundamental Research

    Mumbai, India

    1 h-index

    1 publications

    31 citations

  7. Ege University

    Izmir, Türkiye

    1 h-index

    2 publications

    32 citations

  8. Kookmin University

    Seoul, South Korea

    1 h-index

    1 publications

    16 citations

1–8 of 44

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 95 citations

    2

    h-index

  2. Nature

    1 publications · 189 citations

    1

    h-index

  3. PLoS ONE

    1 publications · 31 citations

    1

    h-index

  4. Biotechnology and Bioprocess Engineering

    1 publications · 16 citations

    1

    h-index

  5. Journal of the American Chemical Society

    JACS · 1 publications · 47 citations

    1

    h-index

1–5