Concepedia

Scaffold-based Library Design

Scaffold-Based Library Design is a combinatorial chemistry methodology in which a common molecular framework (scaffold) is systematically functionalized at specific sites to generate a diverse library of structurally related compounds for high-throughput screening and structure-activity relationship studies.

241

Publications

10.3K

Citations

1.4K

Authors

383

Institutions

Publications per year

2017–2026

67

Parents

Publications

241

ZINC20—A Free Ultralarge-Scale Chemical Database for Ligand Discovery

John J. Irwin, Khanh Tang, Jennifer J. Young et al. · Journal of Chemical Information and Modeling · 2020 · 1K citations · Full text

, , +17

Carbon scaffolding: building acetylenic all-carbon and carbon-rich compounds

François Diederich · Nature · 1994 · 501 citations

, , +15

Scaffold Architecture and Pharmacophoric Properties of Natural Products and Trade Drugs:  Application in the Design of Natural Product-Based Combinatorial Libraries

Man‐Ling Lee, Gisbert Schneider · Journal of Combinatorial Chemistry · 2001 · 293 citations

, , +15

De novo branching cascades for structural and functional diversity in small molecules

M. García-Castro, Lea Kremer, Christopher D. Reinkemeier et al. · Nature Communications · 2015 · 257 citations · Full text

, , +15

Bioactivity-Guided Navigation of Chemical Space

Robin S. Bon, Herbert Waldmann · Accounts of Chemical Research · 2010 · 247 citations

, , +17

1–5 of 241

Authors

1.4K

  1. AN
    Adam Nelson

    University of Leeds, United Kingdom

    8 publications · 519 citations

    8

    h-index

  2. JB
    Jürgen Bajorath

    University of Bonn, Germany

    5 publications · 154 citations

    5

    h-index

  3. HA
    Haoyun An

    Ionis Pharmaceuticals (United States), United States

    4 publications · 98 citations

    4

    h-index

  4. PD
    P. Dan Cook

    Ionis Pharmaceuticals (United States), United States

    4 publications · 98 citations

    4

    h-index

  5. RM
    Rémy Morgentin

    AstraZeneca (France), France

    4 publications · 76 citations

    4

    h-index

1–5 of 1.4K

Institutions

383

  1. University of Leeds

    Leeds, United Kingdom

    8 h-index

    38 publications

    2.4K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    37 publications

    1.1K citations

  3. TU Dortmund University

    Dortmund, Germany

    6 h-index

    26 publications

    3K citations

  4. University of Kansas

    Lawrence, United States

    5 h-index

    21 publications

    667 citations

  5. Chinese Academy of Sciences

    Beijing, China

    5 h-index

    27 publications

    752 citations

  6. University of Pittsburgh

    Pittsburgh, United States

    4 h-index

    12 publications

    326 citations

  7. ETH Zurich

    Zurich, Switzerland

    4 h-index

    14 publications

    1K citations

  8. Novartis (Switzerland)

    Basel, Switzerland

    4 h-index

    6 publications

    188 citations

1–8 of 383

Venues

  1. Journal of Combinatorial Chemistry

    22 publications · 935 citations

    18

    h-index

  2. Organic Letters

    OL · 18 publications · 613 citations

    16

    h-index

  3. Tetrahedron Letters

    15 publications · 402 citations

    13

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    12 publications · 296 citations

    12

    h-index

  5. The Journal of Organic Chemistry

    JOC · 11 publications · 429 citations

    11

    h-index

1–5