Concepedia

Scaffold Redesign

Scaffold Redesign is a methodological contribution in medicinal chemistry that involves the systematic modification of a molecular scaffold to generate novel chemotypes while retaining desired biological activity, distinguishing it from other scaffold hopping approaches by prioritizing structural innovation and patentability.

109

Publications

3.6K

Citations

802

Authors

218

Institutions

Publications per year

2017–2026

35

Parents

Publications

109

Recent advances in the synthesis of biologically active spirooxindoles

Maria M. M. Santos · Tetrahedron · 2014 · 395 citations

, , +13

Engineering an Antibiotic to Fight Cancer: Optimization of the Novobiocin Scaffold to Produce Anti-proliferative Agents

Huiping Zhao, Alison C. Donnelly, Bhaskar Reddy Kusuma et al. · Journal of Medicinal Chemistry · 2011 · 162 citations

, , +16

Discovery of Novel Spiro[3<i>H</i>-indole-3,2′-pyrrolidin]-2(1<i>H</i>)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

Andreas Gollner, Dorothea Rudolph, Heribert Arnhof et al. · Journal of Medicinal Chemistry · 2016 · 121 citations

, , +16

Skeletal diversity construction via a branching synthetic strategy

Emma E. Wyatt, Suzanne Fergus, Warren R. J. D. Galloway et al. · Chemical Communications · 2006 · 94 citations

, , +12

A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool

Ignacio Colomer, Christopher J. Empson, Philip G. E. Craven et al. · Chemical Communications · 2016 · 88 citations · Full text

, , +13

1–5 of 109

Authors

802

  1. AN
    Adam Nelson

    University of Leeds, United Kingdom

    3 publications · 148 citations

    3

    h-index

  2. SP
    Stephen P. Marsden

    University of Leeds, United Kingdom

    3 publications · 148 citations

    3

    h-index

  3. PG
    Philip G. E. Craven

    University of Leeds, United Kingdom

    3 publications · 148 citations

    3

    h-index

  4. RP
    Rune Pagh Nielsen

    Aarhus University, Denmark

    2 publications · 57 citations

    2

    h-index

  5. NI
    Naoki Ishida

    Kyoto University, Japan

    2 publications · 49 citations

    2

    h-index

1–5 of 802

Institutions

218

  1. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    34 publications

    714 citations

  2. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    16 publications

    1.1K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    10 publications

    239 citations

  4. University of Leeds

    Leeds, United Kingdom

    4 h-index

    20 publications

    1K citations

  5. University of Chinese Academy of Sciences

    Beijing, China

    3 h-index

    9 publications

    131 citations

  6. University of Bonn

    Bonn, Germany

    3 h-index

    7 publications

    165 citations

  7. University of Sussex

    Brighton, United Kingdom

    3 h-index

    8 publications

    250 citations

  8. Al-Azhar University

    Cairo, Egypt

    2 h-index

    2 publications

    96 citations

1–8 of 218

Venues

  1. European Journal of Medicinal Chemistry

    11 publications · 259 citations

    11

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    11 publications · 198 citations

    11

    h-index

  3. Bioorganic & Medicinal Chemistry

    11 publications · 276 citations

    10

    h-index

  4. Tetrahedron

    7 publications · 545 citations

    7

    h-index

  5. Journal of Medicinal Chemistry

    6 publications · 465 citations

    6

    h-index

1–5