Impact of Freeze/Thaw Process on Drug Substance Storage of Therapeutics

Surface-Induced Denaturation of Proteins during Freezing and its Inhibition by Surfactants

Byeong S. Chang, Brent S. Kendrick, John F. Carpenter · Journal of Pharmaceutical Sciences · 1996 · 472 citations

Life Sciences, Biochemistry, Protein Biochemistry +11

Effect of freezing and thawing rates on denaturation of proteins in aqueous solutions

Enhong Cao, Yahuei Chen, Zhanfeng Cui et al. · Biotechnology and Bioengineering · 2003 · 389 citations

Life Sciences, Biochemistry, Biophysics +14

Proteins in frozen solutions: evidence of ice-induced partial unfolding

Giovanni B. Strambini, Edi Gabellieri · Biophysical Journal · 1996 · 303 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Protein Stability in Ice

Giovanni B. Strambini, Margherita Gonnelli · Biophysical Journal · 2006 · 92 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Measurement of the Kinetics of Protein Unfolding in Viscous Systems and Implications for Protein Stability in Freeze-Drying

Xiaolin Tang, Michael J. Pikal · Pharmaceutical Research · 2005 · 64 citations

Life Sciences, Biochemistry, Biophysics +16