Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.4K citations

Life Sciences, Cell Biology, Molecular Biology +12

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +15

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Raúl Muñoz-Planillo, Peter Kuffa, Giovanny J. Martínez-Colón et al. · Immunity · 2013 · 2.1K citations

Life Sciences, Immunology, Microbiology +16

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

David Y. Fann, Silvia Manzanero, Mathias Gelderblom et al. · Cell Death and Disease · 2013 · 490 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

Weiguo Peng, Maria Luisa Cotrina, Xiaoning Han et al. · Proceedings of the National Academy of Sciences · 2009 · 425 citations · Full text

Medicine, Neuroscience, Pharmacology +17