NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner, +14

Nature

InflammationSignal TransductionOxysterolBiochemistryCell Signaling +10

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

Paul Angulo, David E. Kleiner, Sanne Dam‐Larsen, +9

Gastroenterology

Metabolic Associated SteatohepatitisFibrosisHepatologyLiver FibrosisNonalcoholic Fatty Liver Disease +12

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae, +19

Nature Medicine

InflammationAnti-inflammatoryAutoimmune DiseaseMedicineNlrp3 Inflammasome +12

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Jorge Henao‐Mejia, Eran Elinav, Chengcheng Jin, +12

Nature

InflammationInflammasome-mediated DysbiosisImmunologyPathologyChronic Inflammation +4

A lipidomic analysis of nonalcoholic fatty liver disease

Rebecca Baillie, Michelle M. Wiest, Faridoddin Mirshahi, +5

Hepatology

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Kristiina Rajamäki, Jani Lappalainen, Katariina Öörni, +4

PLoS ONE

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

Alexander Wree, Akiko Eguchi, Matthew D. McGeough, +5

Hepatology

CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

Isabelle Leclercq, Geoffrey C. Farrell, Jaqueline Field, +3

Journal of Clinical Investigation

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

Kouichi Miura, Yuzo Kodama, Sayaka Inokuchi, +6

Gastroenterology

InflammationToll-like ReceptorsMolecular ImmunologyCytokineToll-like Receptor 9 +12

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

Hae‐Ki Min, Ashwani Kapoor, Michael Fuchs, +7

Cell Metabolism

PathologyFatty Liver DiseaseMetabolic SyndromeMetabolic Associated Steatotic Liver DiseaseNonalcoholic Fatty Liver Disease +15