NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature · 2010 · 3.8K citations · Full text

Inflammation, Signal Transduction, Oxysterol +12

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

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Metabolic Associated Steatohepatitis, Fibrosis, Hepatology +14

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.7K citations · Full text

Inflammation, Anti-inflammatory, Autoimmune Disease +14

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Jorge Henao‐Mejia, Eran Elinav, Chengcheng Jin et al. · Nature · 2012 · 2.4K citations

Inflammation, Inflammasome-mediated Dysbiosis, Immunology +6

A lipidomic analysis of nonalcoholic fatty liver disease

Rebecca Baillie, Michelle M. Wiest, Faridoddin Mirshahi et al. · Hepatology · 2007 · 1.3K citations · Full text