Derrick M. Van Rooyen

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Auvro R. Mridha, Alexander Wree, Avril A. B. Robertson et al. · Journal of Hepatology · 2017 · 1K citations · Full text

Inflammation, Fibrosis, Liver Fibrosis +14

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

Derrick M. Van Rooyen, Claire Z. Larter, W. Geoffrey Haigh et al. · Gastroenterology · 2011 · 342 citations · Full text

Obesity, Metabolic Syndrome, Causes Nonalcoholic Steatohepatitis +12

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

Lay T. Gan, Derrick M. Van Rooyen, Mark E. Koina et al. · Journal of Hepatology · 2014 · 196 citations

Inflammation, Oxysterol, Hepatology +13

Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

Derrick M. Van Rooyen, Lay T. Gan, Matthew M. Yeh et al. · Journal of Hepatology · 2013 · 122 citations

Obesity, Metabolic Syndrome, Metabolic Disorder +9

Peroxisome proliferator‐activated receptor‐α agonist, Wy 14 643, improves metabolic indices, steatosis and ballooning in diabetic mice with non‐alcoholic steatohepatitis

Claire Z. Larter, Matthew M. Yeh, Derrick M. Van Rooyen et al. · Journal of Gastroenterology and Hepatology · 2011 · 87 citations