Mark E. Koina

TLR7 gain-of-function genetic variation causes human lupus

Grant J. Brown, Pablo F. Cañete, Hao Wang et al. · Nature · 2022 · 563 citations · Full text

Life Sciences, Genetics, Immunology +17

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

Lay T. Gan, Derrick M. Van Rooyen, Mark E. Koina et al. · Journal of Hepatology · 2014 · 199 citations

Life Sciences, Biochemistry, Cell Biology +14

Fatty acids alter glycerolipid metabolism and induce lipid droplet formation, syncytialisation and cytokine production in human trophoblasts with minimal glucose effect or interaction

AN Pathmaperuma, Parast M Mana, Scw Cheung et al. · Placenta · 2010 · 84 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy

Binhai Ren, Bronwyn A. O’Brien, M. A. Swan et al. · Diabetologia · 2007 · 75 citations · Full text

Medicine, Endocrinology, Molecular Medicine +15

Mice Deficient in Glutathione Transferase Zeta/Maleylacetoacetate Isomerase Exhibit a Range of Pathological Changes and Elevated Expression of Alpha, Mu, and Pi Class Glutathione Transferases

Cindy Ee Lin Lim, Klaus I. Matthaei, Anneke C. Blackburn et al. · American Journal Of Pathology · 2004 · 70 citations · Full text

Life Sciences, Biochemistry, Genetics +10