Design and validation of a histological scoring system for nonalcoholic fatty liver disease†

David E. Kleiner, Elizabeth M. Brunt, Mark L. Van Natta, +10

Hepatology

Nafld Activity ScoreDiagnosisPathologyGastroenterologyFatty Liver Disease +22

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai, +8

Nature

Toll-like ReceptorsVirulence FactorPathogenesisInnate Immune SystemToll-like Receptor +5

The Inflammasome

Fabio Martinon, Kimberly Burns, Jürg Tschopp

Molecular Cell

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu, +1

Nature

InflammationMitochondrial FunctionCell DeathNlrp3 Inflammasome ActivationInflammasome +5

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner, +14

Nature

InflammationSignal TransductionOxysterolBiochemistryCell Signaling +10

Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome

Giulio Marchesini, Elisabetta Bugianesi, Gabriele Forlani, +8

Hepatology

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Rongbin Zhou, Aubry Tardivel, Bernard Thorens, +2

Nature Immunology

InflammationImmunologyCell DeathInflammasomeRedox Biology +5

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Bolormaa Vandanmagsar, Yun‐Hee Youm, Anthony Ravussin, +6

Nature Medicine

ObesityMetabolic SyndromeInflammationInsulin ResistanceDiabetes +8

Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities

Arun J. Sanyal, Carol Campbell–Sargent, Faridoddin Mirshahi, +6

Gastroenterology

ObesityMetabolic SyndromeInsulin ResistanceMetabolic Associated SteatohepatitisHepatology +9

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Eran Elinav, Till Strowig, Andrew L. Kau, +8

Cell

InflammationChronic Inflammatory DiseasesDysbiosisMucosal ImmunologyImmunology +9