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In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation

BiochemistryMedicineSimultaneous Reversible InhibitionVivo ExtrapolationPharmacotherapySystem PharmacologyPharmacologyComplex Drug-drug InteractionPharmacokineticsTranslational Pharmacology