Concepedia

Cyp2d6-guided Dosing

CYP2D6-Guided Dosing is a personalized dosing strategy that uses genetic and enzymatic activity data of the CYP2D6 enzyme to tailor drug regimens according to an individual’s metabolic phenotype, thereby optimizing therapeutic efficacy and minimizing adverse effects.

87

Publications

5K

Citations

658

Authors

271

Institutions

Publications per year

2017–2026

23

Parents

Publications

87

Clinical pharmacogenetics implementation consortium guideline (CPIC) for <i>CYP2D6</i> and <i>CYP2C19</i> genotypes and dosing of tricyclic antidepressants: 2016 update

JK Hicks, Katrin Sangkuhl, JJ Swen et al. · Clinical Pharmacology & Therapeutics · 2016 · 678 citations · Full text

, , +17

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants

J. Kevin Hicks, Jesse J. Swen, Caroline F. Thorn et al. · Clinical Pharmacology & Therapeutics · 2013 · 453 citations · Full text

, , +17

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype

Kristine R. Crews, Andrea Gaedigk, Henry M. Dunnenberger et al. · Clinical Pharmacology & Therapeutics · 2011 · 368 citations · Full text

, , +17

Genotype-Guided Tamoxifen Dosing Increases Active Metabolite Exposure in Women With Reduced CYP2D6 Metabolism: A Multicenter Study

William Irvin, Christine M. Walko, Karen E. Weck et al. · Journal of Clinical Oncology · 2011 · 179 citations

, , +17

CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial

D. Max Smith, Kristin Weitzel, Amanda R. Elsey et al. · Genetics in Medicine · 2019 · 155 citations · Full text

, , +17

1–5 of 87

Authors

658

  1. TC
    Todd C. Skaar

    Indiana University – Purdue University Indianapolis, United States

    6 publications · 1.1K citations

    6

    h-index

  2. AG
    Andrea Gaedigk

    Children's Mercy Hospital, United States

    5 publications · 1.6K citations

    5

    h-index

  3. HG
    Henk‐Jan Guchelaar

    Leiden University Medical Center, Netherlands

    5 publications · 278 citations

    5

    h-index

  4. RH
    Ron H. N. van Schaik

    Erasmus MC, Netherlands

    5 publications · 190 citations

    5

    h-index

  5. VO
    Vincent O. Dezentjé

    Leiden University Medical Center, Netherlands

    4 publications · 211 citations

    4

    h-index

1–5 of 658

Institutions

271

  1. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    9 h-index

    27 publications

    3.7K citations

  2. Leiden University Medical Center

    Leiden, The Netherlands

    7 h-index

    39 publications

    3.3K citations

  3. Indiana University School of Medicine

    Indianapolis, United States

    5 h-index

    18 publications

    2.6K citations

  4. University of Michigan

    Ann Arbor, United States

    5 h-index

    7 publications

    1.5K citations

  5. Erasmus MC

    Rotterdam, The Netherlands

    5 h-index

    27 publications

    1.4K citations

  6. University of Washington

    Seattle, United States

    4 h-index

    13 publications

    727 citations

  7. Children's Mercy Hospital

    Kansas City, United States

    4 h-index

    4 publications

    1.5K citations

  8. Karolinska Institutet

    Stockholm, Sweden

    4 h-index

    15 publications

    581 citations

1–8 of 271

Venues

  1. Breast Cancer Research and Treatment

    11 publications · 505 citations

    11

    h-index

  2. European Journal of Clinical Pharmacology

    10 publications · 379 citations

    10

    h-index

  3. Journal of Clinical Oncology

    4 publications · 355 citations

    4

    h-index

  4. Clinical Pharmacology & Therapeutics

    CPT · 4 publications · 1.6K citations

    4

    h-index

  5. Clinical Drug Investigation

    3 publications · 90 citations

    3

    h-index

1–5