Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design

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Jonathan B. Singer, Steve Lewitzky, Elisabeth Leroy et al. · Nature Genetics · 2010 · 388 citations

Life Sciences, Immunology, Pharmacology +14

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

Shintaro Nakayama, Ryo Atsumi, Hideo Takakusa et al. · Drug Metabolism and Disposition · 2009 · 248 citations

Pharmacy, Pharmacology, Toxicology +17

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Michael D. Aleo, Yi Luo, Rachel Swiss et al. · Hepatology · 2014 · 214 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

Richard A. Thompson, Emre M. Isin, Yan Li et al. · Chemical Research in Toxicology · 2012 · 214 citations

Pharmacy, Pharmacology, Toxicology +17

A high content screening assay for identifying lysosomotropic compounds

Sashi Nadanaciva, Shuyan Lu, David F. Gebhard et al. · Toxicology in Vitro · 2010 · 205 citations

Life Sciences, Biochemistry, Molecular Biology +11