Thiazolidinedione Bioactivation:  A Comparison of the Bioactivation Potentials of Troglitazone, Rosiglitazone, and Pioglitazone Using Stable Isotope-Labeled Analogues and Liquid Chromatography Tandem Mass Spectrometry

Rubén Alvarez‐Sánchez, François Montavon, Thomas Härtung, +1

Chemical Research in Toxicology

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease

Edilio Borroni, Bernd Bohrmann, Fiona Grueninger, +13

Journal of Pharmacology and Experimental Therapeutics

PharmacotherapyAlzheimer ’Oxidative StressMolecular PharmacologyAlzheimer's Disease +15

Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats

Wolfgang Völkel, Rubén Alvarez‐Sánchez, Idelette Weick, +3

Free Radical Biology and Medicine

BiochemistryLiver PhysiologyPhysiologyLipid PeroxidationGlutathione Conjugates +8

Rapid detection and identification of<i>N</i>-acetyl-<i>L</i>-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass spectrometer

Karoline Scholz, W. Dekant, Wolfgang Völkel, +1

Journal of the American Society for Mass Spectrometry

Biotransformation of Perchloroethene: Dose-Dependent Excretion of Trichloroacetic Acid, Dichloroacetic Acid, andN-acetyl-S-(trichlorovinyl)-l-Cysteine in Rats and Humans after Inhalation

Wolfgang Völkel, Marion Friedewald, Elke Lederer, +3

Toxicology and Applied Pharmacology

Dichloroacetic AcidBiochemistryTrichloroacetic AcidMedicinePhysiology +9

Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease

Wolfgang Völkel, Tina Sicilia, Axel Pähler, +7

Neurochemistry International

Severe AlzheimerAlzheimer's Disease4-Hydroxy-2-nonenal Glutathione ConjugatesDementiaBrain Levels +9

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1<i>H</i>-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

Georg Jaeschke, Sabine Kolczewski, Will Spooren, +31

Journal of Medicinal Chemistry

Psychotropic MedicationPsychopharmacologyPharmacotherapyPsychiatric DiseasesPharmaceutical Chemistry +17

Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists

Guido Galley, Angélica Beurier, Guillaume Décoret, +10

ACS Medicinal Chemistry Letters

Drug TargetActive Taar1 AgonistsPharmacotherapySelective Taar1 LigandsAdrenergic Compound 1 +15

Post‐acquisition analysis of untargeted accurate mass quadrupole time‐of‐flight MS ^E data for multiple collision‐induced neutral losses and fragment ions of glutathione conjugates

Andreas Brink, Fabien Fontaine, Michaela Marschmann, +4

Rapid Communications in Mass Spectrometry

Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design

Andreas Brink, Axel Pähler, Christoph Funk, +2

Drug Discovery Today

Medicinal ChemistryNew Drug CandidatesPreclinical Drug EvaluationBiochemistryDrug Design +11