In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

Richard A. Thompson, Emre M. Isin, Yan Li, +10

Chemical Research in Toxicology

ImmunologyPharmacotherapyIadrs AriseToxicological MechanismAdverse Drug Reaction +19

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

Richard A. Thompson, Emre M. Isin, Yan Li, +7

Chemico-Biological Interactions

Risk AssessmentReactive MetabolitesPredictive ToxicologyBiochemistryMedicine +8

IL-6 receptor expression and IL-6 effects change during osteoblast differentiation

Yan Li, Carl‐Magnus Bäckesjö, Lars-Arne Haldosén, +1

Cytokine

InflammationSclerostinBone Morphogenic ProteinImmunologyOsteoarthritis +7

Development of a Brigatinib degrader (SIAIS117) as a potential treatment for ALK positive cancer resistance

Ning Sun, Chaowei Ren, Ying Kong, +10

European Journal of Medicinal Chemistry

MedicinePharmacologyBrigatinib DegraderAnti-cancer AgentCancer Treatment +4

Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction

Xing Qiu, Ning Sun, Ying Kong, +3

Organic Letters

Medicinal ChemistryChemoselective SynthesisBet ProteinBiochemistryNatural Sciences +9

Inducible Degradation of Oncogenic Nucleolin Using an Aptamer-Based PROTAC

Miao Chen, Ping Zhou, Yun Kong, +7

Journal of Medicinal Chemistry

Proteolysis-targeting ChimerasInducible DegradationDrug DiscoveryBioconjugationOligonucleotide +11

A Strategy for the Improvement of the Bioavailability and Antiosteoporosis Activity of BCS IV Flavonoid Glycosides through the Formulation of Their Lipophilic Aglycone into Nanocrystals

Yan Li, Shaoping Sun, Qi Chang, +5

Molecular Pharmaceutics

Pharmaceutical ScienceNanotherapeuticsBio-based NanomaterialsPolysaccharideIct Surface +18

Population pharmacokinetics of pomalidomide

Yan Li, Yejun Xu, Liangang Liu, +3

The Journal of Clinical Pharmacology

UrologyHealthy SubjectsMedicineChronic Kidney DiseaseHematology +8

Exploring the impact of inoculum dose on host immunity and morbidity to inform model-based vaccine design

Andreas Handel, Yan Li, Brian McKay, +3

PLoS Computational Biology

ImmunologyHost ImmunityFlu VaccinationImmunotherapyCross-protection +14

Body roundness index is related to the low estimated glomerular filtration rate in Chinese population: A cross-sectional study

Yue Zhang, Wenxing Gao, Rui Ren, +13

Frontiers in Endocrinology