Xing Qiu

Effective degradation of EGFRL858R+T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems

Xiaojuan Qu, Haixia Liu, Xiaoling Song et al. · European Journal of Medicinal Chemistry · 2021 · 112 citations

Life Sciences, Biochemistry, Molecular Biology +17

Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction

Xing Qiu, Ning Sun, Ying Kong et al. · Organic Letters · 2019 · 74 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Development of a Brigatinib degrader (SIAIS117) as a potential treatment for ALK positive cancer resistance

Ning Sun, Chaowei Ren, Ying Kong et al. · European Journal of Medicinal Chemistry · 2020 · 74 citations · Full text

Medicine, Oncology, Pharmacology +14

Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation

Haixia Liu, Xinyu Ding, Linyi Liu et al. · European Journal of Medicinal Chemistry · 2021 · 55 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +6

Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile

Chaowei Ren, Ning Sun, Haixia Liu et al. · Journal of Medicinal Chemistry · 2021 · 38 citations · Full text

Medicine, Molecular Biology, Oncology +14