Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer

Jingjing Qi, Hongxiang Sun, Yao Zhang, +18

Nature Communications

Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis

Zhenzhen Xun, Xinyu Ding, Yao Zhang, +8

Nature Communications

Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase

Quanju Zhao, Chaowei Ren, Linyi Liu, +12

Journal of Medicinal Chemistry

25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

Jun Xiao, Shuang Wang, Longlong Chen, +18

Immunity

InflammationOxysterolMetabolic ReprogrammingImmunologyVascular Biology +6

Suppression of Cyclin D1 by Hypoxia-Inducible Factor-1 via Direct Mechanism Inhibits the Proliferation and 5-Fluorouracil–Induced Apoptosis of A549 Cells

Wen Wen, Jin Ding, Wen Sun, +11

Cancer Research

Cyclin D1ApoptosisCell DeathDirect MechanismCancer Biology +20

Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways

Jie Min, Li Xu, Kenan Huang, +5

Oncology Reports

Chemoprevention StrategyLung InflammationApoptosisPathologyCell Death +16

Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis

Yuye Yin, Xinyi Yang, Shusheng Wu, +9

Nature Immunology

InflammationRheumatologyRheumatoid DisorderInflammatory DiseaseAutoimmune Disease +8

Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation

Haixia Liu, Xinyu Ding, Linyi Liu, +11

European Journal of Medicinal Chemistry

BiochemistryNatural SciencesSynthetic BiologyMolecular BiologyNovel Bcr-abl Protacs +3

Profiling of immune features to predict immunotherapy efficacy

Youqiong Ye, Yongchang Zhang, Nong Yang, +18

The Innovation

RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial‐mesenchymal transition and proliferation in endometriosis

Zhixiong Huang, Xiao‐Mei Mao, Rongfeng Wu, +4

Journal of Cellular and Molecular Medicine

EndometriosisGynecologyFemale Reproductive FunctionMenstrual CycleOvarian Aging +18