Concepedia

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

Xiaotian Zhang, Jianzhong Su, Mira Jeong, Myunggon Ko, Yun Huang, Hyun Jung Park, Anna Guzman, Yong Lei, Yung‐Hsin Huang, Anjana Rao,

Nature Genetics · 2016 · 262 citations · 64 references

Concepts

Life SciencesGeneticsMolecular BiologyEpigeneticsStem Cell BiologyTranscriptional RegulationCell Lineage SpecificationHematopoietic DevelopmentHematopoietic DifferentiationHematopoietic Stem Cell BiologyHematopoietic Stem CellsLineage CommitmentCell-type-specific Transcription FactorsGene-specific Transcription FactorsHematopoietic Lineage SpecificationHematopoietic Stem Cell Epigenetic RegulationHematopoietic Stem Cell Lineage CommitmentHematopoietic Stem Cell Transcriptional RegulationStem Cell Gene Regulation

References

64

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha et al. · Proceedings of the National Academy of Sciences · 2005 · 56.7K citations · Full text

Life Sciences, Bioinformatics, Oncology +12

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang, Tao Liu, Clifford A. Meyer et al. · Genome biology · 2008 · 19.9K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +11

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Mamta Tahiliani, Kian Peng Koh, Yinghua Shen et al. · Science · 2009 · 5.8K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

New England Journal of Medicine · 2013 · 5.2K citations · Full text

Medicine, Genetics, Molecular Genetics +12

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Siddhartha Jaiswal, Pierre Fontanillas, Jason Flannick et al. · New England Journal of Medicine · 2014 · 4.7K citations · Full text

Life Sciences, Genetics, Hematology +17