Concepedia

Cell Lineage Specification

Cell Lineage Specification is the developmental process by which a cell commits to a specific fate within a differentiated cell lineage, based on intrinsic and extrinsic regulatory cues that distinguish it from alternative cell fates within the broader category of cell fate determination.

1.9K

Publications

244.8K

Citations

9.9K

Authors

1.7K

Institutions

Publications per year

2017–2026

438

Parents

Children

Publications

1.9K

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Sven Heinz, Christopher Benner, Nathanael J. Spann et al. · Molecular Cell · 2010 · 14.6K citations · Full text

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Matrix Elasticity Directs Stem Cell Lineage Specification

Adam J. Engler, Shamik Sen, H. Lee Sweeney et al. · Cell · 2006 · 13.7K citations · Full text

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The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Cole Trapnell, Davide Cacchiarelli, Jonna Grimsby et al. · Nature Biotechnology · 2014 · 7.8K citations · Full text

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Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

Hitoshi Niwa, Jun‐ichi Miyazaki, Austin Smith · Nature Genetics · 2000 · 3.6K citations

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Multipotent cell lineages in early mouse development depend on SOX2 function

Ariel A. Avilion, Silvia K. Nicolis, Larysa Pevny et al. · Genes & Development · 2003 · 2.4K citations · Full text

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1–5 of 1.9K

Authors

9.9K

  1. TE
    Tariq Enver

    University College London, United Kingdom

    14 publications · 2.6K citations

    14

    h-index

  2. EV
    Ellen V. Rothenberg

    California Institute of Technology, United States

    15 publications · 1.7K citations

    14

    h-index

  3. BG
    Berthold Göttgens

    University of Cambridge, United Kingdom

    13 publications · 1.6K citations

    13

    h-index

  4. AS
    Austin Smith

    Wellcome/MRC Cambridge Stem Cell Institute, United Kingdom

    10 publications · 5.7K citations

    10

    h-index

  5. SH
    Sui Huang

    Institute for Systems Biology, United States

    10 publications · 3K citations

    10

    h-index

1–5 of 9.9K

Institutions

1.7K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    69 h-index

    367 publications

    76.1K citations

  2. Harvard University

    Cambridge, United States

    62 h-index

    398 publications

    128.6K citations

  3. University of Cambridge

    Cambridge, United Kingdom

    49 h-index

    257 publications

    41.3K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    43 h-index

    255 publications

    27K citations

  5. National Institutes of Health

    Bethesda, United States

    38 h-index

    264 publications

    45.4K citations

  6. University of Pennsylvania

    Philadelphia, United States

    37 h-index

    170 publications

    81.5K citations

  7. Stanford University

    Stanford, United States

    37 h-index

    224 publications

    32.4K citations

  8. Harvard Stem Cell Institute

    Cambridge, United States

    32 h-index

    124 publications

    44.7K citations

1–8 of 1.7K

Venues

  1. Development

    144 publications · 18.3K citations

    69

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 90 publications · 10.1K citations

    51

    h-index

  3. Blood

    75 publications · 9.4K citations

    49

    h-index

  4. Developmental Biology

    86 publications · 8.3K citations

    48

    h-index

  5. Cell

    53 publications · 33.7K citations

    47

    h-index

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