Mutant NPM1 Maintains the Leukemic State through HOX Expression

Lorenzo Brunetti, Michael C. Gundry, Daniele Sorcini, +14

Cancer Cell

Genome InstabilityMutant Npm1Molecular BiologyMedicineCell Biology

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

Xiaotian Zhang, Jianzhong Su, Mira Jeong, +9

Nature Genetics

Lineage-specific Transcription FactorsLineage PlasticityCell LineageMedicineGenetics +10

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

Mira Jeong, Hyun Jung Park, Hamza Celik, +10

Cell Reports

Bloodstream Cells Phenotypically Identical to Human Mesenchymal Bone Marrow Stem Cells Circulate in Large Amounts Under the Influence of Acute Large Skin Damage: New Evidence for Their Use in Regenerative Medicine

Eduardo Mansilla, Hugo Drago, F. Sturla, +10

Transplantation Proceedings

Regenerative MedicineCell TherapyHealth SciencesMedicineAdult Stem Cell +10

DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells

Tianpeng Gu, Xueqiu Lin, Sean M. Cullen, +17

Genome biology

The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development

Tianpeng Gu, Dapeng Hao, Junsung Woo, +12

Nature Genetics

Developmental BiologyDisordered N-terminal DomainGenetic DisorderDevelopmental GeneticsGenetics +6

A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

Lei Guo, Jia Li, Hongxiang Zeng, +10

Nature Communications

Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis

Xiaotian Zhang, Xinyu Wang, Xue Qing David Wang, +11

Blood

Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies

Hongxiang Zeng, Hailan He, Lei Guo, +11

Cancer Letters

Hematological MalignancyMedicineMalignant Blood DisorderHematologyImmunology +7

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion

Ayala Tovy, Jaime M. Reyes, Michael C. Gundry, +21

Cell stem cell

ChromatinGenome InstabilityChromatin RemodelingEpigenetic ChangeGenetics +10