Mutant NPM1 Maintains the Leukemic State through HOX Expression

Lorenzo Brunetti, Michael C. Gundry, Daniele Sorcini, +14

Cancer Cell

Genome InstabilityMutant Npm1Molecular BiologyMedicineCell Biology

Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

Michael C. Gundry, Lorenzo Brunetti, Angelique Lin, +8

Cell Reports

Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein

Yong Lei, Xiaotian Zhang, Jianzhong Su, +6

Nature Communications

DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A

Yung‐Hsin Huang, Jianzhong Su, Yong Lei, +6

Genome biology

Direct, genome-wide assessment of DNA mutations in single cells

Michael C. Gundry, Wenge Li, Shahina B. Maqbool, +1

Nucleic Acids Research

Dna DamageGeneticsMutational HeterogeneityGenomic MechanismSingle Cells +14

5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1

Alexander Y. Maslov, Moonsook Lee, Michael C. Gundry, +6

Oncogene

5-Aza-2′-deoxycytidine-induced Genome RearrangementsChromatinGenome InstabilityChromatin RemodelingMedicine +6

Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity

Amy E. Pohodich, Hari Krishna Yalamanchili, Ayush T. Raman, +7

eLife

Large-scale GMP-compliant CRISPR-Cas9–mediated deletion of the glucocorticoid receptor in multivirus-specific T cells

Rafet Başar, May Daher, Nadima Uprety, +35

Blood Advances

Cell TherapyIn Vivo Gene TherapyImmunologyCd4 T Cell ResponsesMultivirus-specific T Cells +15

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion

Ayala Tovy, Jaime M. Reyes, Michael C. Gundry, +21

Cell stem cell

ChromatinGenome InstabilityChromatin RemodelingEpigenetic ChangeGenetics +10

Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

Lorenzo Brunetti, Michael C. Gundry, Ayumi Kitano, +2

Journal of Visualized Experiments

Systems BiologyEngineeringOff-target EffectGeneticsImmunology +11