GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway

Multiplex Genome Engineering Using CRISPR/Cas Systems

Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.4K citations

Single Crispr Array, Engineering, Short Rnas +12

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

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Off-target Effect, Engineering, Genome Surgery +12

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

Yanfang Fu, Jennifer A Foden, Cyd Khayter et al. · Nature Biotechnology · 2013 · 3.3K citations · Full text

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

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Signal Transduction, Receptor Tyrosine Kinase, Physiology +7

Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart

Chen‐Leng Cai, Xingqun Liang, Yunqing Shi et al. · Developmental Cell · 2003 · 1.6K citations · Full text

Cardiac Muscle, Cell Lineage, Cardiomyopathy +12