Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons

α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

Jacqueline Burré, Manu Sharma, Theodoros Tsetsenis et al. · Science · 2010 · 1.8K citations · Full text

Synaptic Transmission, Molecular Biology, High Frequency +20

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

Kelly A. Conway, Seung‐Jae Lee, Jean‐Christophe Rochet et al. · Proceedings of the National Academy of Sciences · 2000 · 1.5K citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

Kazumitsu Ueda, Hideto Fukushima, Eliezer Masliah et al. · Proceedings of the National Academy of Sciences · 1993 · 1.5K citations · Full text

Peptide Engineering, Molecular Biology, Social Sciences +17

Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease

Wei Zhang, Tongguang Wang, Zhong Pei et al. · The FASEB Journal · 2005 · 1.3K citations

Neurodegenerative Diseases, Resident Microglia, Nadph Oxidase +14

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

Tim Bartels, Joanna G. Choi, Dennis J. Selkoe · Nature · 2011 · 1.2K citations · Full text

Neurodegenerative Diseases, Protein Folding, Molecular Biology +4