Concepedia

Highly Regioselective Halogenation of Pyridine <i>N</i>-Oxide: Practical Access to 2-Halo-Substituted Pyridines

Ying Chen, Jinkun Huang, Tsang‐Lin Hwang, Maosheng J. Chen, Jason S. Tedrow, Robert Farrell, Matthew M. Bio, Sheng Cui

Organic Letters · 2015 · 50 citations · 14 references

DOI

Concepts

Abstract

A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a practical access to various 2-halo-substituted pyridines, which are pharmaceutically important intermediates.

References

14

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Discovery, Synthesis, and Bioactivity of Bis(heteroaryl)piperazines. 1. A Novel Class of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

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An Efficient, Regioselective Amination of 3,5-Disubstituted Pyridine <i>N</i>-Oxides Using Saccharin as an Ammonium Surrogate

Robert Farrell, Maria Victoria Silva Elipe, Michael D. Bartberger et al. · Organic Letters · 2012 · 56 citations

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