Concepedia

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

Gerard E. Kaiko, Hyunji Ryu, Olivia I. Koues, Patrick L. Collins, Lilianna Solnica‐Krezel, Edward J. Pearce, Erika L. Pearce, Eugene M. Oltz, Thaddeus S. Stappenbeck

Cell · 2016 · 723 citations · 47 references

DOIFull text

Open access

Concepts

References

47

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature · 2009 · 7.2K citations

, , +14

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature · 2007 · 5.7K citations

, , +16

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda et al. · Nature · 2013 · 5.3K citations

, , +14

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T <sub>reg</sub> Cell Homeostasis

Patrick M. Smith, Michael R. Howitt, Nicolai Panikov et al. · Science · 2013 · 5.3K citations · Full text

, , +17

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Nicholas Arpaia, Clarissa Campbell, Xiying Fan et al. · Nature · 2013 · 4.7K citations · Full text

, , +14