Concepedia

Exosome‐mediated activation of toll‐like receptor 3 in stellate cells stimulates interleukin‐17 production by γδ T cells in liver fibrosis

Wonhyo Seo, Hyuk Soo Eun, So Yeon Kim, Hyon‐Seung Yi, Young‐Sun Lee, Seol‐Hee Park, Mi‐Jin Jang, Eun‐Jung Jo, Sun Chang Kim, Yong‐Mahn Han,

Hepatology · 2016 · 173 citations · 28 references

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Abstract

In liver injury, the exosome-mediated activation of TLR3 in HSCs exacerbates liver fibrosis by enhancing IL-17A production by γδ T cells, which might be associated with HSC stimulation by unknown self-TLR3 ligands from damaged hepatocytes. Therefore, TLR3 might be a novel therapeutic target for liver fibrosis. (Hepatology 2016;64:616-631).

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Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis

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