Nature · 2016 · 1K citations · 46 references
Life SciencesMolecular BiologyMolecular GeneticsGenetic EngineeringGenome EditingGenome EngineeringCrispr-based EngineeringCrispr-cas SystemsGene Knockout StrategiesMutagenesis StrategiesTarget Site SelectionTherapeutic Genome EditingCrispr Guide Rna DesignCrispr-based Genome EngineeringCrispr-cas Genome EditingCrispr-cas9 Genome EditingCrispr-cas9 Knockout
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li, Richard Durbin · Bioinformatics · 2009 · 62.8K citations · Full text
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.7K citations
Fast and accurate long-read alignment with Burrows–Wheeler transform
Heng Li, Richard Durbin · Bioinformatics · 2010 · 12.9K citations · Full text
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali, Luhan Yang, Kevin M. Esvelt et al. · Science · 2013 · 9.4K citations · Full text
PEAR: a fast and accurate Illumina Paired-End reAd mergeR
Jiajie Zhang, Kassian Kobert, Tomáš Flouri et al. · Bioinformatics · 2013 · 4.9K citations · Full text