Concepedia

Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials

G G Chabot, D Abigerges, G. Catimel, Stéphane Culine, M Forni, Jean Marc Extra, M. Mahjoubi, Patrice Herait, Jean‐Pierre Armand, R. Bugat

Annals of Oncology · 1995 · 173 citations · 44 references

DOI

Concepts

References

44

Reporting results of cancer treatment

A. B. Miller, Barth Hoogstraten, M. Staquet et al. · Cancer · 1981 · 7.9K citations

, , +16

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

, , +15

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

Yasuyoshi Kawato, Masashi Aonuma, Yasuhide Hirota et al. · PubMed · 1991 · 874 citations

, , +13

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

Yaw Huei Hsiang, Leroy F. Liu · PubMed · 1988 · 844 citations

, , +12

Biopharmaceutics and clinical pharmacokinetics

General Pharmacology The Vascular System · 1991 · 696 citations

, , +11