Concepedia

PHLPP2 down regulation influences nuclear Nrf2 stability via Akt-1/Gsk3β/Fyn kinase axis in acetaminophen induced oxidative renal toxicity: Protection accorded by morin

Alpana Mathur, Fatima Rizvi, Poonam Kakkar

Food and Chemical Toxicology · 2016 · 47 citations · 29 references

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Concepts

References

29

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

Donna D. Zhang, Mark Hannink · Molecular and Cellular Biology · 2003 · 1.4K citations · Full text

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PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth

Tianyan Gao, Frank B. Furnari, Alexandra C. Newton · Molecular Cell · 2005 · 911 citations · Full text

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Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Deepti Malhotra, Élodie Portales-Casamar, Anju Singh et al. · Nucleic Acids Research · 2010 · 781 citations · Full text

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PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms

John Brognard, Emma Sierecki, Tianyan Gao et al. · Molecular Cell · 2007 · 578 citations · Full text

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GSK-3β Acts Upstream of Fyn Kinase in Regulation of Nuclear Export and Degradation of NF-E2 Related Factor 2

Abhinav K. Jain, Anil K. Jaiswal · Journal of Biological Chemistry · 2007 · 469 citations · Full text

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