PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms

John Brognard, Emma Sierecki, Tianyan Gao, +1

Molecular Cell

Molecular PhysiologySignal TransductionAkt SignalingSignaling PathwayNatural Sciences +12

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

Andrew J. Brooks, Wei Dai, Megan L. O’Mara, +16

Science

Human GrowthMolecular BiologyGrowth Hormone ReceptorSignaling PathwayReceptor Tyrosine Kinase +16

Lateral mobility of proteins in liquid membranes revisited

Yann Gambin, Ricardo López-Esparza, Myriam Reffay, +5

Proceedings of the National Academy of Sciences

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Mehdi Moustaqil, Emma Ollivier, Hsin-Ping Chiu, +10

Emerging Microbes & Infections

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Thomas Ve, Parimala R. Vajjhala, Andrew Hedger, +17

Nature Structural & Molecular Biology

Signal TransductionNatural SciencesMolecular BiologyGene RegulationStructural Basis +7

Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt

Pingping Wang, Zhihong Zhou, Anchang Hu, +13

Molecular Cell

Tumor BiologySignal TransductionSignaling PathwayCell RegulationMedicine +8

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

Yann Gambin, Nicholas Ariotti, Kerrie‐Ann McMahon, +16

eLife

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential

Bjoern Meyer, Jeanne Chiaravalli, Stacy Gellenoncourt, +16

Nature Communications

Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies

Chi L.L. Pham, Nirukshan Shanmugam, Merryn Strange, +6

EMBO Reports

Viral M45ImmunologyVirologyDegenerative PathologyProtein Misfolding +2

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

Max T. B. Clabbers, Susannah Holmes, Timothy W. Muusse, +22

Nature Communications