John Brognard

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

John Brognard, Amy S. Clark, Yucheng Ni et al. · PubMed · 2001 · 892 citations

Chemoprevention Strategy, Immunology, Cell Death +22

PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms

John Brognard, Emma Sierecki, Tianyan Gao et al. · Molecular Cell · 2007 · 573 citations · Full text

Molecular Physiology, Signal Transduction, Akt Signaling +14

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

Kip A. West, John Brognard, Amy S. Clark et al. · Journal of Clinical Investigation · 2003 · 511 citations · Full text

Asthma, Apoptosis, Cell Death +19

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

Kip A. West, John Brognard, Amy S. Clark et al. · Journal of Clinical Investigation · 2003 · 498 citations · Full text

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

Corina E. Antal, Andrew Hudson, Emily L. Kang et al. · Cell · 2015 · 330 citations · Full text

Tumor Biology, Cell Regulation, Medicine +9