Frank B. Furnari

PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth

Tianyan Gao, Frank B. Furnari, Alexandra C. Newton · Molecular Cell · 2005 · 904 citations · Full text

Signal Transduction, Signaling Pathway, Suppresses Tumor Growth +12

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

Kristen M. Turner, Viraj Deshpande, Doruk Beyter et al. · Nature · 2017 · 854 citations

Somatic Variant, Tumor Heterogeneity, Genetics +4

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

David A. Nathanson, Beatrice Gini, Jack Mottahedeh et al. · Science · 2013 · 665 citations · Full text

Circular ecDNA promotes accessible chromatin and high oncogene expression

Sihan Wu, Kristen M. Turner, Nam Nguyen et al. · Nature · 2019 · 659 citations · Full text

Chromatin, Dna, Chromatin Structure +10

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

Maria-del-Mar Inda, Rudy Bonavia, Akitake Mukasa et al. · Genes & Development · 2010 · 537 citations · Full text

Biological Microenvironments, High-grade Gliomas, Cancer Biology +16